Pain Management

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Pain Management Research

Current

 

The Development and Implementation of a Collaborative Health Outcomes Information Registry for the Weill Cornell Multidisciplinary Spine Center

Principal InvestigatorLisa Witkin, M.D.

Summary: This study aims to develop and implement a patient-reported outcomes data collection system for the Weill Cornell Center for Comprehensive Spine Care. Ideally, this will allow ongoing treatment to be determined by the patients' response and progress. CHOIR (Collaborative Health Outcomes Information Registry; software developed by Stanford University) data can also inform clinical research by longitudinally tracking individual patients as well as allow for aggregate data analysis to improve evidence-based medicine guidance of treatment.

Status: Open

RELIEF A Global Registry to Evaluate Long-Term Effectiveness of Neurostimulation Therapy for Pain

Principal InvestigatorShakil Ahmed, M.B. B.S.

Summary: This study, sponsored by Boston Scientific, is a prospective, multi-center, global registry of Boston Scientific neurostimulation systems for pain. The endpoints of this registry are intended to provide a broad evidence base to assess long-term clinical and economic outcomes of BSC neurostimulation systems in a large number of subjects representing real-world use patterns. The registry will also bridge the existing evidence gap in disease management, treatment effectiveness, health economic value, and patient outcomes for on-label use of the systems.

Status: Open

A Post-Market, Multicenter, Prospective, Randomized, Clinical Trial Comparing 10 kHz Spinal Cord Stimulation (HF10 Therapy) Combined with Conventional Medical Management to Conventional Medical Management Alone in the Treatment of Chronic, Intractable, Neuropathic Limb Pain

Principal InvestigatorNeel Mehta, M.D.

Summary: The purpose of this Nevro-sponsored, post-market study is to document comparative safety, clinical effectiveness, and cost-effectiveness of the addition of Nevro HF10 therapy to Conventional Medical Management (CMM) compared with CMM alone in subjects with chronic, intractable, neuropathic lower limb pain due to diabetic neuropathy (Painful Diabetic Neuropathy or PDN). This study is a multi-center, prospective, randomized comparison of the two treatments.

Status: Pending 

Utility of MRI in Assessing Gaps in Ligamentum Flavum in Planning for Cervical Epidural Steroid Injection 

Principal Investigator: Jatin H. Joshi, M.D.

Summary: This study will assess the utility of pre-procedural MRI in evaluating gaps in ligamentum flavum in planning for cervical epidural steroid injections.  We would like to quantify the probability of identifying gaps in ligamentum flavum by MRI. Using MRI, the goal is to evaluate the rate of midline gaps in the ligamentum flavum in the cervical spine region. Subsequent analysis will also evaluate the prevalence of ligamentum flavum gaps in the thoracic and lumbar space.

Status: Open

Comparison of Conventional Abdominopelvic CT and CT Thoracolumbar Angiogram for the Detection of Spinal Arteries in the Thoracolumbar Spine, a Retrospective Review

Principal Investigator: Neel Mehta, M.D.

Summary: The purpose of this study is to quantify the probability of locating spinal arteries and precisely define their location because identifying thoracolumbar spinal arteries with conventional CT is not consistent. The goal of this study is to compare conventional CT's ability to detect spinal arteries against CT Angiogram's, which remains the gold standard at detecting the presence of spinal arteries, and to define a "safer zone" for injection targeting the splanchnic nerves of the sympathetic chain by quantifying the probability of locating spinal arteries above, at, or below the pedicular level.

Status: Open

The Association between Obesity, Pain Severity, Pain Interference, and Opioid Consumption

Principal Investigator: Lisa R. Witkin, M.D. 

Summary: The purpose of this study is to evaluate the association of obesity as a risk factor for pain outcomes, as a predictor of opioid consumption, and as a predictor of high risk opioid use. Outcomes of interest include: (1) pain severity, (2) pain interference, (3) and opioid consumption. The hypothesis is that a higher level of obesity would be associated with increased levels of pain outcomes and opioid consumption.

Status: Open

Spinal Cord Stimulator Education during Pain Fellowship: Unmet Training Needs and Factors that Impact Future Practice

Principal Investigator: Neel Mehta, M.D.

Summary: The purpose of this study is to evaluate why fellows choose or not choose to practice SCS after pain fellowship. The hypothesis is that there are unmet needs in fellowship education that hinder future SCS practice by pain physicians. Fellows will be contacted via emails provided by their respective fellowship directors to fill out a survey through SurveyMonkey (the "In-Fellowship Survey") that will assess their interest and expertise in SCS prior to/ during fellowship and their future SCS practice goals.

Status: Open

Chronic Pain Registry

Principal Investigator: Lisa Witkin, M.D.

The purpose of this project is to establish a retrospective chronic pain patient data registry for patients with chronic pain, and to use the patient data registry along with Practice Based Evidence (PBE) and Clinical Practice Improvement (CPI) methodology to identify specific pain management interventions that are most effective for specific patient types with chronic pain. Data is retrospectively reviewed from surveys that chronic pain patients at the WCMC Pain Management Center, the Pain and Palliative Care Clinic at MSKCC and the Hospital for Special Surgery fill out as part of their routine clinical visits.

Status: Open

Analysis of Pain-Related Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) Free Text Responses

Principal Investigator: Neel Mehta, M.D.

Summary: The purpose of this study is to utilize the free text responses within HCAHPS to identify unmet needs that could potentially improve patient perception of care at Weill Cornell Medicine/NYP. We hope that this knowledge will enable the development of patient-oriented approaches to pain management.

Status: Open

Past

 

Validity of Prism-5-Op Interviews for Use in Studies of Prescription Opioids

Principal Investigator: Neel Mehta, M.D.

Summary: This study, a collaboration with the New York State Psychiatric Institute, aims to help standardize the definition of addiction for chronic pain patients prescribed opioids for pain treatment by determining the validity and reliability of PRISM-5-Op diagnoses of DSM-5 Substance Use Disorder for prescription opioids, and to determine the feasibility of the PRISM-5-OP test for the FDA required prospective cohort studies and for future use.

Status: Closed 

PROMISE (Prospective, Randomized Study of Multicolumn Implantable Lead Stimulation for Predominant Low Back Pain)

Principal Investigator: Neel Mehta, M.D.

Summary: The purpose of this Medtronic-sponsored study is to compare the effectiveness of spinal cord stimulation (SCS) using the Medtronic Specify® 5-6-5 multicolumn surgical lead plus optimal medical management (OMM) versus OMM alone in patients suffering from predominant low back pain due to failed back surgery syndrome (FBSS).

Status: Closed 

Predicting oxycodone dose from oral fluid drug levels for chronic pain medicine patients

Principal Investigator: Neel Mehta, M.D.

Study analyzing the opioid drug levels in three different samples from chronic pain patients who are regularly taking opioid medications. Patients must be between 18-72 years of age, suffer from chronic pain, be taking prescribed opioid medication and must not have any chronic liver or kidney diseases or impairments. Subjects provide a blood, urine, and saliva sample which is analyzed at a laboratory. Enrollment is complete once the subject gives the samples.

Status: Closed

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